The Best Supplements for Histamine Intolerance: My Top Picks for Symptom Relief
If you’re dealing with histamine intolerance, you already know how challenging it can be to manage.
From unexpected food reactions to digestive discomfort, histamine overload can turn everyday foods and environments into a minefield.
While addressing the root causes of histamine intolerance—such as gut health or nutrient deficiencies—is key, there are several supplements that can offer relief by supporting the body’s ability to process histamine.
In this post, I’m excited to share my favourite supplements for managing histamine intolerance, ones I use personally and recommend to my clients who are dealing with this condition.
The best quality supplements that truly work and heal rather than harm do not come cheap, so I have also put together some discounts for you.
These are general supplements that benefit most people. However if histamine intolerance manifests in a particular area, such as insomnia or anxiety for an individual, then I would add in additional support for this. If you need any suggestions for this, just get in touch.
Remember, everyone’s body is different, so what works for one person may not work for another. Always listen to your body and keep a record to understand what does and doesn’t work best for you. Histamine Intolerance can be tricky and cause some individuals to react badly to supplementation.
I would also ideally want to rule out SIBO first, as this may alter which supplements are recommend, especially some probiotics as they may make certain symptoms like constipation worse.
Okay here we go, these are my miracle potions…
Quercetin
Quercetin is a natural bioflavonoid found in foods like apples, onions, and capers, and it's known for its potent antihistamine and anti-inflammatory properties. Quercetin helps to stabilise mast cells, which are the cells that release histamine during allergic reactions. It also has the added benefit of being a strong antioxidant.
How it helps: By reducing the release of histamine from mast cells, quercetin can help lower overall histamine levels in the body, making it an excellent daily supplement for those with chronic histamine issues.
When to use: Quercetin can be taken daily to prevent histamine release, or as needed during allergy seasons or when exposed to high-histamine foods or environments.
Vitamin C
Vitamin C is not only a powerful antioxidant but also a natural antihistamine. It works by degrading excess histamine in the body and has been shown to reduce blood histamine levels, making it an essential supplement for those with histamine intolerance.
How it helps: Regular intake of vitamin C can help break down histamine, support immune function, and reduce the intensity of allergic reactions.
This is my favourite blend because it combines quercitin with various antihistamine nutrients and mast cell stabilisers such as Vitamin C.
You can purchase it here using my discount code KP10.
Probiotics
While not all probiotics are helpful for histamine intolerance, certain strains can actually help reduce histamine levels in the gut. Look for probiotics that are known to degrade histamine rather than produce it.
Best strains for histamine intolerance:
Bifidobacterium infantis
Bifidobacterium longum
Lactobacillus rhamnosus
Avoid strains like Lactobacillus casei and Lactobacillus bulgaricus, as they may produce histamine in the gut.
How it helps: Supporting a healthy gut microbiome can aid in reducing histamine production in the digestive system and enhance overall gut health which supports DAO production.
This is my favourite because it is formulated specifically for those with histamine issues and does not contain any probiotic strains that trigger histamine issues. You can order it here using discount code SFYT0O
DAO (Diamine Oxidase) Enzyme Supplements
DAO supplements are a go-to for many people with histamine intolerance. DAO is the enzyme responsible for breaking down histamine in the gut.
In those with histamine intolerance, low levels of DAO are often the reason histamine builds up and causes symptoms.
How it helps: Taking a DAO supplement before meals can assist in breaking down histamine from food, preventing or reducing symptoms like headaches, bloating, or hives.
When to use: DAO is best taken 15 minutes before meals that may contain higher histamine levels (think fermented foods, aged cheese, or cured meats. I also take it with the occasional cheeky glass of wine).
You can order it here using discount code SFYT0O
Lamb Kidney is also high in DAO and is an effective way of breaking down histamine from foods. I love this brand because they are a truly ethical company who put welfare and sustainability at the heart of what they do, and create products that are designed to optimise health. This supplement is grass fed and with no fillers or bulking agents which can be difficult for those with histamine issues. Essentially both this supplement and the Histamine Digest do the same job, so you only want to take one. You will probably find that one of them works more effectively for you, so feel free to try them both interchangeably.
You can purchase it here with a 10% discount along with most of the other supplements recommended in this post.
Toxaprevent Supplements
Not only do we want to support histamine metabolism but it is also important to lower the histamine burden by detoxing and excreting histamine from the body. This product has truly been a revelation on my personal journey and for my clinical practice.
The most effective way to restore histamine balance is by implementing a multi pronged approach, which entails a variety of treatment options. When we do this we manage histamine so much more effectively.
The sooner we can lower our histamine load the quicker symptoms will resolve and we become less reactive to foods. Think of histamine like a bucket effect; as it fills it causes more and more unpleasant symptoms. If we can empty the bucket quickly, then we will stabilise the condition and feel so much healthier.
Toxaprevent also works to heal the mucosal lining of the gut which is often the cause of issues with DAO enzyme production. It’s expensive but an absolute miracle for those of us with Histamine Intolerance.
For those that are sensitive it’s best to start with the capsules and then move onto to adding in the sachets.
“The active ingredient MANC® (Modified and Activated Natural Clinoptilolite) is a clean form of zeolite which is patented for its ability to bind and remove heavy metals (lead and mercury), histamine and ammonium from the body. MANC® does this by binding these harmful substances, which are linked to symptoms of fatigue, food intolerances, intestinal inflammation and autoimmune conditions, as it passes through the intestinal tract. Both MANC and the toxins it has bound, are then removed from the body via natural bowel movements as the body cannot absorb MANC®”.
You can purchase the capsules and sachets here using my discount code KP10.
For more information you can visit their website here.
Magnesium
Magnesium is a key mineral for overall health, and it also has anti-histamine properties. It helps stabilise mast cells and reduces histamine release, making it a valuable supplement for anyone dealing with histamine intolerance. It can also be helpful for those who struggle with multiple histamine symptoms such as anxiety, insomnia, restless legs and period cramps.
How it helps: Magnesium not only reduces histamine release but also helps improve sleep, reduce stress, and support muscle relaxation—areas often impacted by histamine overload.
When to use: Magnesium can be taken daily, either through diet or supplementation. I like to take it just before sleep to aid in relaxation.
Vitamin B6
Vitamin B6 plays a critical role in the function of DAO. Without sufficient B6, DAO production may be impaired, leading to a decrease in histamine breakdown. People with histamine intolerance often benefit from ensuring their B6 levels are optimised.
How it helps: Supplementing with vitamin B6 can support the production and activity of DAO, helping to manage histamine levels in the body more effectively.
When to use: Consider taking a daily B6 supplement or a good-quality B-complex to ensure you’re supporting DAO activity.
Viridian do a great Magnesium and B6 combination that you can purchase here using my discount code KP10.
Colostrum
Colostrum is an excellent supplement for histamine intolerance because of its powerful ability to support gut health and reduce inflammation. Colostrum, the nutrient-rich first milk produced by mammals after giving birth, contains a range of immune-boosting compounds, including immunoglobulins, growth factors, and lactoferrin.
These components help to heal the gut lining, reduce intestinal permeability (leaky gut), and support the immune system. Since many cases of histamine intolerance are linked to poor gut health or inflammation, colostrum can enhance the body’s ability to regulate histamine and promote better tolerance by improving gut integrity and reducing histamine-triggering inflammation. It is usually well tolerated in those with Histamine Intolerance and is my go to if other options are not.
I love this brand because they only use surplus colostrum and ensure that the calves get their fill from the mothers first. It is also organic and grass fed which is important when it comes to dairy, higher welfare and better for your health and the planet. For those that struggle with lactose this is also lactose free.
You can buy it here using code KP10.
While supplements can be incredibly helpful in managing histamine intolerance, it’s crucial to remember that they work best when combined with a holistic approach. Dietary changes, lifestyle adjustments, and addressing any underlying health issues (such as gut health) are key components of managing histamine levels effectively.
Supplements can offer a huge amount of relief short term but unless the underlying causes of histamine intolerance are addressed you will never find lasting and longterm relief.
Histamine intolerance doesn’t have to control your life—there are plenty of tools and supplements that can help bring balance and relief!
Always consult with your GP or healthcare provider before starting any new supplement, especially if you are taking prescription medications. Some supplements may interact with medications, and it's important to ensure that they are safe for your specific health needs.